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Receptor uncoupling [edit] Receptor uncoupling/phosphorylation is the most rapid form of desensitization that happens within a cell, as its effects are seen within seconds to minutes of agonist application

Subsequently, the pRB-E2F-TAg complex associates with Hsc70 in the presence of ATP as Hsc70 ATP-bound form presents high substrate association rate to facilitate TAg-Hsc70 complex formation

Peer review Peer review information Nature Communications thanks Toni Giorgino and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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