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doi: 10.1016/j.abb.2005.06.010
The dose delivered to the body can be far higher than from a cream or tablet, since injected substances bypass digestion and the skin barrier and go straight into the tissues at full strength

Martnez-Smano, J

Dietary supplement use among adults: United States, 20172018

Visible skin brightening typically becomes more apparent over a series of treatments, depending on individual health status and dosage