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2023 Dec Leane Hoey, J J Strain, Helene McNulty

doi: 10.1038/s41598-023-37720-x 44 DassN

SIBO (small intestinal bacteria overgrowth) Intestinal Candida or other fungal infections Food poisoning Gluten, dairy and other inflammatory foods Chronic stress emotional or physical Traumatic brain injury or concussion Pesticides and other chemicals Certain medications including antibiotics and non-steroidal anti-inflammatories Caesarean birth (baby isnt exposed to helpful vaginal flora) Radiation therapy Being underweight especially babies, children, or teenagers

People commonly notice their energy picking up, their thinking feeling clearer, and that general heaviness starting to lift

These side effects vary between different types of CD38 inhibitors due to different mechanisms of inhibition, effect on the cyclase vs NADase activity of CD38, tissue distribution, and pharmacokinetic profiles