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This is a somewhat uncommon posttranslational modification of the protein, which is then known as a "Gla protein"

Zigman, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

With an increase in oxidative stress, Nrf2 is released and translocates to the nucleus, where it binds and activates the ARE and upregulates several genes associated with glutathione synthesis and antioxidant defense (Figure 2) [45,48]

The optimal sensitivity and specificity were 86% and 83%, respectively