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patients who have had inhalation treatments of acetylcysteine without incident may still react to subsequent inhalation with increased airways obstruction

Additionally, dysregulated iron metabolism contributes to pathogenesis, as iron-loaded exosomes released by intestinal epithelial cells are recognized and internalized via macrophage scavenger receptor 1, triggering oxidative stress and inflammatory responses that exacerbate mucosal injury (171)

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No evidence of rebound neutropenia or persistent neutropenia was observed after rhG-CSF administration, indicating that antibody-mediated adverse effects did not occur