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Description
Moran, J
Roshanzadeh G, Jahanian Sadatmahalleh S, Moini A, Mottaghi A, Rostami F
Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy
From a clinical perspective, it suggests that in disease states with high IL-5 (like hypereosinophilic syndromes or active IBD with a type 2 skew), targeting Siglec-8 could be especially effective in depleting pathogenic eosinophils
Human safety data is limited, so its full risk profile is not established
