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To maintain the appropriate level of reduced Trx1, oxidized Trx1 is reduced by an enzyme called Trx reductase 1 (TrxR1) and the reducing agent NADPH [11] (Figure 4)

Liu et al., 2018), with lifestyle and microbiota-based treatments specially tailored toward the specific needs of the patients could be more efficacious in the management of CKD and related complications