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The toxic 14-methyl sterols are problematic because accumulation of these aberrant sterols interrupts proper packing of acyl chains in the phospholipid bilayer and they abnormally interact with other components of the membrane, causing a disruption of ideal structure and functionality [138,139]

Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trial

however, its pathogenesis arises from a combination of multiple factors (213216)

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