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Diethylnitrosamine-induced liver cancer involves CUGBP1 phosphorylation, which activates translation of CEBPB and HDAC1 via the CUGBP1-eIF2 complex, leading to CEBPB-HDAC1-mediated repression of p53, SIRT1, and PGC1 promoters, thereby promoting liver proliferation and disrupting functional regulation from quiescent to cancerous stages [67]
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Table 9.3
