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showed that the melanocortin-derived tripeptide KPV produced significant anti-inflammatory effects in DSS colitis and CD45RBhi transfer colitis models two of the most commonly used and accepted IBD research paradigms.1 Critically, the anti-inflammatory effect persisted even in animals with a nonfunctional MC1R receptor, confirming that KPV's action does not depend on melanocortin signaling

These symptoms occur most frequently during treatment initiation and dose escalation, with median durations of 2-8 days per episode

[DOI] [PubMed] [Google Scholar] 29.Sherje A.P., Londhe V

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