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Studies reporting experimental evidence of enzymatic inhibition or chemosensory interference were prioritized and integrated with mortality and repellency data

Sirtuins, particularly SIRT1, need NAD+ as a cofactor for protein deacetylation

Improper Antibiotic Timing Antibiotics kill both harmful and beneficial bacteria indiscriminately

Essential B vitamins Additional support for healthy energy and metabolism

Combined with the RMSD analysis, it can be inferred that after the fluctuation in the first 200 ns, the conformation of CME_b undergoes changes, making it more similar to the characteristics of CME_a.In the CME_c binding mode, the L1 and L4 regions exhibit significant fluctuations during the simulation (Fig