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If the deficiency is severe, remarkably, it can lead to permanent nerve damage

M.WeiX.KikukawaY.TzameliI.PrasadD.et al (2015)

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

In some patients, particularly high doses of B12 can trigger a breakout of acne
