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Hydroperoxide reduction by thioredoxin-specific glutathione peroxidase isoenzymes of Arabidopsis thaliana

In contrast, individuals with SLE have reduced diversity of gut microbiota, with a structural and functional disorder known as dysbiosis ( Firmicutes and Bacteroidetes together account for approximately 98% of the bacterial community, low F/B ratio is linked to gut microbiota dysbiosis, once more pointing to microbial imbalance as being key to SLE pathogenesis ( SLE patients are usually characterized by a condition called leaky gut, which is compromised integrity of the intestinal barrier

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mtROS further contributes to vascular remodeling by inducing smooth muscle cell proliferation and endothelial apoptosis via oxidative DNA damage (8-OHdG) and lipid peroxidation (MDA)