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Understanding biochemical processes as the proposal of successful disease treatment

The study quality evaluation rationales are available in an interactive Tableau dashboard in the study quality evaluation heatmap Evidence Synthesis and Integration The overall study confidence was considered when synthesizing epidemiologic and animal toxicological health effect evidence

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The riskbenefit assessment for wellness or anti-aging interventions may differ substantially from that applied to disease-specific therapeutic indications, given the differing clinical objectives and risk tolerances

Ethics declarations Funding This work was funded by the National Institutes of Health/National Institute of Neurological Disorders and Stroke (R01NS120926 and R01NS127188 to S.A.G.), the Centers for Disease Control and Prevention/Agency for Toxic Substances and Disease Registry (R01TS000344 and R01TS000327 to S.A.G.), and James and Margaret Hiller and Linda and Eric Novak (S.A.G.)