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However, whether the previously reported lower level of glutathione peroxidase-1 (GPX1) demonstrated in mouse and human islets by Western blotting and enzyme assays is also an intrinsic feature of human beta cells in situ is unclear (Grankvist et al

Under oxidative stress, NRF2 translocates into the nucleus and forms a heterodimer with small musculoaponeurotic fibrosarcoma proteins and binds to the antioxidant response element consensus sequence for transcriptional regulation (196) ( Figure 3 )

Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors

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doi: 10.7759/cureus.27438
