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For example, TPA and EG, the main intermediate products of PET degradation, might display unforeseen effects on the microorganisms in the surrounding environment

The rats were housed at a temperature of about 21-23 C, under a 12/12-h light/dark cycle and ambient humidity of 30-50%

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However, research shows that genetics alone is not usually the sole cause

This activation leads to the activation of the NADPH oxidase (NOX) complex, producing reactive oxygen species (ROS), which in turn activate peptidylarginine deiminase 4 (PAD4)