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It has several causes

In a new study, published online December 8, 2023 in Cell Reports , researchers at Sanford Burnham Prebys, with collaborators elsewhere, describe a novel molecular link between vitamin B 12 and MS that takes place in astrocytes important non-neuronal glial cells in the brain

They can figure out the best dose (and source) of the nutrient for you

Even the small folate cycle can only proceed to a limited extent because the supply of THF from the large folate cycle is no longer given