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NSC48160, a Kirsten rat sarcoma viral oncogene homolog (KRAS) inhibitor, indirectly suppresses the NRF2-SLC7A11-GPX4 axis by disrupting the tricarboxylic acid (TCA) cycle, thereby promoting ferroptosis in KRAS-mutant HCC models [47]

Caspases are synthesized as proenzymes and require proteolytic processing to be catalytically active

77 Administration of oral L-Cysteine to patients with cirrhosis has been noted to cause a twofold greater maximal plasma cysteine concentration and plasma elimination half-life, and a delayed excretion of metabolic end products when compared with those of controls

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SAMe application alleviated these injuries in rats that underwent BDL (56)