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Comprehensive toxicology evaluations reveal that the compound does not affect food intake, body temperature regulation, or basic physiological parameters at effective doses in animal models, indicating that its metabolic effects occur through specific pathway modulation rather than general physiological disruption

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Cellular NAD+ Salvage Pathways: Examining changes in intracellular Nicotinamide Adenine Dinucleotide (NAD+) pools resulting from decreased NNMT activity, and its subsequent impact on sirtuin activity and mitochondrial bioenergetics