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The most important of these are polymorphisms in the promoter of the INS (insulin) gene, which modulate intrathymic insulin expression and can impair the elimination of insulin-responsive T cells during central tolerance

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Since discontinuing vitamin B12 supplementation for such a long time may have an adverse effect on the clinical condition of the patient, shorter, effective schemes of desensitization with this vitamin are sought

Research is ongoing to establish safe and effective therapeutic applications

In addition, the prolonged retention of drugs in the lungs because of impaired clearance mechanisms can reduce the intended effects of the treatment and increase the risk of side effects