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We hypothesize that reduced CPT-I activity may contribute to persistent fatigue in these congenital hypothyroid patients, even after levothyroxine therapy, which alone may be insufficient to fully address the downstream metabolic consequences of TPO and TSHR gene mutations present in this cohort

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Effects of LC, NR and the COMBI treatment on hepatic gene expression was analyzed by gene enrichment analysis across pathways and biological processes with the Ingenuity Pathway Analysis suite (IPA

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