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[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

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Tentative efficacy thresholdsdrawn from preclinical and clinical datainclude a 20% reduction in MDA, 30% increase in SOD activity, and measurable improvement in TEWL and tissue regeneration [155,156,157,158]

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These findings suggest that topiramate may exert dual effects on oxidative stress, offering neuroprotection in certain contexts while exacerbating oxidative stress under different conditions and dosages