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Overall, this in vivo microdialysis study provided strong evidence that the disruption of D2R-DAT by the TAT-DAT NT peptide results in an increased extracellular dopamine level

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The process highlights the importance of both peptide flexibility and conformational adaptability in overcoming the hydrophobic and steric challenges of lipid membranes, which is particularly relevant for designing peptides with improved mucosal permeability [74]

Gastrointestinal Tract Research Investigational studies have yielded quantifiable data on mucosal barrier integrity parameters, epithelial junction markers, and gastric tissue matrix measurements in research settings