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Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome
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Contreras E, Carlos R
lifespan extension was limited to females in mice heterozygous for mTOR and its cofactor mammalian lethal with Sec 13 protein 8 (mLST8) (Lamming et al., 2012), while in a mTOR-hypomorphic mouse model lifespan is extended in both males and females (Wu et al., 2013)

In such cases, rashes may develop at the injection site as a sign of irritation