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sublingual/injection routes can bypass this

In addition, a very fresh fecal smear (ideally sampled directly from the rectum) can be placed onto a slide with a drop of saline and looked at under the microscope to observe for movement (giardia may also be seen with this technique and look similar to tritrichomonas, however, tritrichomonas tend to wiggle forward, whereas giardia move in a swirling or 'falling-leaf' pattern)

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(2014, Nature Medicine) established NNMT as a major regulator of metabolic rate in white adipose tissue, showing that NNMT knockdown in mice produced a lean phenotype with elevated energy expenditure providing the foundational rationale for NNMT inhibition as a metabolic research target

Arch Intern Med 165: 1167-1172