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Description
KLF4, a zinc finger transcription factor, can be induced by IL-4 and IL-13 and is essential for M2 polarization by promoting the expression of M2-associated genes

Theyre wanting a certain amount of certitude that, frankly, is appropriate for most drugs, but not for this moment. Regulatory shortcuts exist that would allow the FDA to skip the more laborious approval process
This approach helps identify best dosing for specific research outcomes

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doi:10.1054/ghir.2001.0232 3