glutathione peroxidase glutathione adduct of 4-hne Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis Malondialdehyde (MDA) and 4-hydroxynonenal (HNE)

National Institutes of Health, Bethesda, MD, USA)

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& Cecchini, A

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The integration of kinase (PKA, CDK5, GSK3) and small G-protein (IQGAP1) signalling pathways through CaMKK2, all of which have demonstrated links with human bipolar disorder, points to the possibility that bipolar disorder is a signalopathy that stems from defects in this signal transduction network, and potentially explains the clinical heterogeneity and polygenic nature of the condition