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No dramatic differences in biomass between W303-1b/G, W303-1b/F, W303-1b/gsh1/F, W303-1b/P or W303-1b/P and original strain W303-1b were observed during shake flask cultures (Fig

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However, it characterized the paradox of timolol concomitant to epinephrine to enhance the ocular hypotensive effects in many patients [66]