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AKRs and Cancer Hallmarks Tumor development is a multistep process that involves the acquisition of eight biological capabilities, referred to as cancer hallmarks , namely sustained proliferation, circumventing growth suppressors, cell death evasion, replicative immortality, stimulating angiogenesis, invasion, metastasis, reprogramming cellular metabolism, and overcoming immune destruction

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Levy G, Garrettson LK, Soda DM

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