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In addition, under certain pathological conditions, certain cells can also enter the brain parenchyma in order to maintain the relative homeostasis of the brain microenvironment

Recent evidence showed that imbalances of metal ions (Fe 3+ , Cu 2+ , Zn 2+ and Al 3+ ) homeostasis had implicated them with A aggregation and subsequent induction of oxidative damage

Cancer: the preconditioning factor in pathogenesis

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Moreover, the efficacy of AKR1B1 inhibitors in mouse models supports their use to treat these allergic conditions (Yadav et al., 2011b, 2013a)