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Using pharmacophore models and LigandScout, the researchers were able to identify potential pharmacological targets that might be used in the treatment of diabetes
IGF-DES and IGFBP Biology Research Research using radiolabelled des(1-3)IGF-1 as a probe confirmed that IGFBP-3 is as potent as unlabelled IGF-1 in displacing it from cell surface binding providing evidence that IGFBP-3 can modulate IGF-1R access via a cellular mechanism distinct from simple extracellular sequestration, a key finding in IGFBP-IGF-1R interaction research
However, further research is needed to optimize their dosing and delivery to the brain while minimizing side effects
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Treatment of inflammatory bowel disease: A comprehensive review
