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Vegetarian sources include Brazil nuts, sunflower seeds, and brown rice

In particular, low-grade production of pro-inflammatory cytokines including IL-6, IL-1 and TNF appear to be significant mediators of age-related damage to a wide variety of tissues

Li X, Bi X, Wang S, Zhang Z, Li F, Zhao AZ (2019) Therapeutic Potential of -3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases

More work on this is required before a consensus can be reached

Safety Profile and Contraindications While human clinical trials specifically for joint applications have not been conducted, AOD-9604 has been extensively studied in clinical trials for metabolic applications
