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Groups More Likely to Experience Nausea Clinical data indicate that nausea is more common in: First-time PT-141 users Patients receiving higher initial doses Premenopausal women treated for hypoactive sexual desire disorder (HSDD) Those with prior medication sensitivity or a history of motion sickness Additional caution is warranted in patients with cardiovascular disease due to the medications potential effects on blood pressure

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More recent community-based studies, including analyses from the MESA cohort, further support the prognostic role of TMAO in predicting ASCVD events and mortality [52]