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37 Most affected dogs have increased hepatic copper, which has been described as centrilobular (zone 3) or diffuse.36, 37, 38 Copper concentrations exceeded 2000 g/g dry weight in 10 of 12 dogs (mean copper: 3369 g/g
10.1039/D2RA00809B 186 ShelarA.SinghA

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Excessive ROS production leads to oxidative stress, a significant risk factor for the initiation and progression of atherosclerosis [67,68]
