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doi: 10.1002/cpt1976192213

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This is because since training itself increases fitness, it's generally less likely for a supplement to cause further significant increases in performance when taken by a trained population

2017 NNMT knockdown in adipocytes was associated with improved markers of insulin sensitivity and glucose uptake in preclinical in vitro models, linking NNMT to metabolic homeostasis

Patients who are also optimizing hormonal status should be aware that sex hormones interact with MOTS-c signaling
