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The monomer not only increases ICAM-1, VCAM-1, E-selection, decay-accelerating factor (CD55), and membrane cofactor protein (CD46) and protectin (CD59) expression on endothelial cells, but it also activates the classic complement pathway (in both alive and necrotic cells), inhibits alternative complement pathway stimulation, and decreases the deposition of the opsonic C3b via the lectin pathway [76,77]

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