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One would hope that thorough evaluation of the comparative effectiveness over years of treatment with these medications will follow, to inform clinical decision-making

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Conversely, the GHSR/Foxo1 axis promotes TGF-1 secretion in macrophages via PKA-mediated phosphorylation of Foxo1 at S273, activating hepatic stellate cells and exacerbating inflammatory infiltration, thus aggravating carbon tetrachloride-induced liver fibrosis (174)