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Zinc is known to have concentration-dependent effects on ACE-2 activity as it has low affinity-binding sites for zinc ( in-vitro and human clinical studies demonstrate the antiviral activity of zinc such as inhibiting coronavirus Rdrp template binding/elongation and reduction in outbreak recurrence in the case of herpes simplex virus in human subjects (37)

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Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease