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& Rayman, M

As ROS accumulate, they damage mitochondrial DNA and cellular membranes, leading to inefficient adenosine triphosphate (ATP) production

In CRC, autophagy markers Beclin-1 and Ras-related in brain 7 (Rab-7) have been correlated with treatment resistance and poor survival (Koustas et al., 2019)

Cleavage of GCLC occurs at Asp 499 within the sequence AVVD 499 G, which is located upstream of Cys 553 thought to be important for disulfide bond formation with GCLM [35,45]

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