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GSOR is then cleaved into GSSG and ROH by a second nucleophilic substitution by the GSH molecule according to a mechanism that is not yet fully elucidated ( 2 to 10 4 M -1 s -1 ) measured in steady-state conditions in the range of those of TRX- and GRX-dependent thiol peroxidases ( 7 s -1 for some thiol peroxidases
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ACS Chem Neurosci 9(7):16801692
Sonnewald and Schousboe 2016)
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