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In addition to durability, NA provides rapid, NIR-triggered on-demand cisplatin release (70% in 5 min) and prevents premature leakage, offering spatial and temporal control

While short-term use may cause only transient effects, prolonged supraphysiological IGF-1 receptor activation could potentially cause unwanted tissue growth including cardiac hypertrophy, which at extreme levels could impair cardiac function, and growth of other organs

Under 150 lbs or Over 250 lbs Most peptide protocols use fixed dosing, not weight-based dosing

IMPLICATIONS FOR GH REPLACEMENT Regardless of the exact mechanisms, the insulin antagonistic effects may cause concern when replacing adult GH deficient patients with GH, since some of these patients are insulin resistant in the untreated state

In our study, Nrf2 WT and KO thyroid organoids differentiated with TSH instead of cAMP showed the same down-regulation in Tg mRNA expression, suggesting that the effect is mainly driven by the lack of Nrf2 biding to the ARE sequence of Tg promoter