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Sympatholysis enhances the release of local endogenous, short-lived vasodilators such as adenosine, ATP, prostaglandins, prostacyclin, bradykinin, and protons to act as a compensatory mechanism (58)

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Its a derivative of angiotensin IV, a peptide in the reninangiotensin system, but was chemically modified to make it far more potent and stable
Both events required medical intervention to treat symptoms

Chem Commun 55(60):1035910375 Wang Y, Wang J, Gao M, Zhang X (2015) An ultra hydrophilic dendrimer-modified magnetic graphene with a polydopamine coating for the selective enrichment of glycopeptides
