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*Correspondence: Youcheng Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The brains susceptibility to oxidative stress is thought to be a major contributing factor to AD (Rummel and Butterfield, 2022) The A may bind to loosely bound metal ions (copper and ion), which are abundant in the brain and have a high concentration in the senile plaques of AD patients, stimulating the generation of ROS very effectively (Kim and Lee, 2021