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Precautions include avoiding use in those with cobalt allergy

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In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

Interventions to modulate NAD + levels Several strategies have been developed to modulate NAD + metabolism, both for mechanistic investigation purposes and to assess their potential therapeutic effects to improve health in aging or disease