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The PACS2/CPT1A/DHODH signaling pathway may be involved in ferroptosis in diabetic cardiomyopathy by regulating mitochondrial function in cardiomyocytes [102]

Quercitin upregulates occludin, claudin-1, claudin-3, claudin-4, and claudin-7 in Caco2 cells.[21] Epigallocatechin gallate upregulates IFN- in T84 cells.[22] Berberine upregulates claudin-1 and claudin-2 in HT29/B6 cells.[23] Curcumin upregulates ZO-1, and claudin-1 in CaCo2 cells.[24] Medicinal phototherapeutic herbs such as: Camellia sinensis improves the intestinal barrier, alleviating dysbacteriosis

Subsequently, it promotes the release of a variety of inflammatory cytokines, such as IL-1, TNF-, IL-10, and neutrophil chemotactic factors (such as IL-8), recruits leukocytes in the liver, and amplifies the inflammatory cascade (Tang et al., 2012