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In fact, strategies aimed at buffering microenvironment pH before administration of standard chemotherapy have been proposed by both preclinical 42 and clinical studies [Clinical trials NCT01198821] 43
The inhibition of mitochondrial bioenergetic function by hyperoxia results in mitochondrial dysfunction, evidenced by a reduced membrane potential (Audi et al
[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Yeh CC, Hou MF, Wu SH, Tsai SM, Lin SK, Hou LA, et al
The methods used to increase the intracellular levels of glutathione that have shown efficacy are the administration of compounds that favor cysteine availability [45]
Heparan sulfate proteoglycans
