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Lancet HIV (2019) 3

Krug I, Behrens M, Esselen M, Humpf HU

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Impairment of protein folding mechanisms: chaperonopathies In Section Molecular chaperones: Facilitators of protein folding dynamics, we introduced molecular chaperones, enzymes that can regulate protein folding by interacting with and/or modifying unfolded proteins

Sure, but you're going to overcome it by taking sufficient methylated B vitamins anyway
