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Chronic treatment with AOD 9604 in obese mice produced significant weight reduction and changes in fat pad weight

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Treatment of such an overdose would be mainly supportive, since there is no specific antagonist for B vitamin excess

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When cysteine residues in KEAP1 are oxidized by increasing levels of reactive molecules such as ROS and RNS, NRF2 is released allowing it to migrate to the nucleus and activate the expression of genes encoding proteins with cytoprotective functions

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Higher doses and shorter durations fit acute healing

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