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Similar content being viewed by others Introduction The transcriptional coregulator and a core component of the Polycomb Repressive Deubiquitinase (PR-DUB) complex, ASXL1 (additional sex combs like 1), is frequently mutated and truncated in human malignances, particularly in acute and chronic myeloid leukemias (AML and CML, respectively) and myelodysplastic syndromes (MDS) 1,2,3,4,5,6,7 (Fig

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The endogenous production of creatine and enzymes such as arginine: glycine amidinotransferase (AGAT) is responsible for its production, which is facilitated in the kidney [71,72]

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