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found in their study that in clear cell renal cell carcinoma (ccRCC) tumor cells, endogenous Gln metabolism might reduce the anti-tumor effectiveness of T cells by promoting the Treg cell response (41)
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226,227 The major DNA adduct formed is the 1,4-interstand cross-link
Additionally, CSCs actively contribute to the remodeling of the TME by secreting various metabolites, thereby creating a favorable ecological environment for tumor initiation and progression (74)
